AIC Committee

Members of the Advanced Imaging Center

Dr. Eduardo Rosa-Molinar (Chairman) and Jose L. Serrano-Velez

University of Kansas
Microscopy and Analytical Imaging Resources Core Laboratory Professor
1200 Sunnyside Avenue
Lawrence, Kansas 66045
Email: erm@ku.edu
Eduard Rosa - Spinal Motor Neurons

Eduardo Rosa-Molinar, Ph.D. is a Professor of Pharmacology and Toxicology and Neuroscience Graduate Program and Director of the Microscopy and Analytical Imaging Resource Core Laboratory at the University of Kansas. Until June 2015, he was a tenured Professor of Integrative Anatomy and Neurobiology, University of Puerto Rico-Rio Piedras, San Juan Puerto Rico.

Ed Rosa-Molinar

Rosa-Molinar and his group focuses on the “neural microcircuits", a specific pattern of interconnections between neurons and synapses within a specific region of the central nervous system (i.e., spinal cord); they image and study the three-dimensional (3-D) nano-scale geometry of synapses. We are particularly interested in “mixed synapses”, a poorly studied synapse that combines the features of both chemical and electrical synapses (i.e., gap junction).

Please visit our web site at: https://pharmtox.ku.edu/eduardo-rosa-molinar.

Dr. Rainer Pepperkok

Team Leader and Head of Dept.
Adv. Light Microscopy Core Facility
EMBL Heidelberg, Meyerhofstraße 1
69117 Heidelberg, Germany

Molecular biology is evolving at a dizzying pace. As this science shifts its emphasis to new biological problems, incorporating new investigative methods and techniques, instruments must keep up with the latest developments and biologists must have access to state-of-the-art equipment and high quality training in its use. These are the goals of the new Advanced Light Microscopy Facility at the European Molecular Biology Laboratory's main facility in Heidelberg.

  • PhD - University Kaiserslautern, Germany (1992)
  • Postdoctoral work at University of Geneva, Switzerland
  • Lab Head at the Imperial Cancer Research Fund, London, UK
  • Team Leader at EMBL since 1998

Please visit our web site at: http://www.embl.de/services/core_facilities/almf

Dr. Paul T. Matsudaira

Department of Biological Science
National University of Singapore
14 Science Drive 4
Singapore 117543
Email: dbshead@nus.edu.sg

Paul Matsudaira The Whitehead·MIT BioImaging Center brings together a diverse and distinguished group of faculty from the Whitehead Institute and MIT biology, chemistry, computer science, and bioengineering departments along with research scientists, graduate students, and post-docs, all with a common belief: that complex cellular processes can best be understood by seeing with sophisticated imaging techniques, and then understanding the images through powerful computational methods.

A nexus for technology development, the BioImaging Center seeks to expand the frontiers of molecular imaging by building and beta-testing new instruments, applying powerful computational models to acquired data, and advancing commercial and clinical applications. Collaborative, curious, and committed, the BioImaging Center is a valuable resource to the global research community.

Please visit our web site at: http://www.wi.mit.edu/research/faculty/matsudaira.html

Dr. Xuejun Sun

Faculty Services Officer IV
Experimental Oncology
Department of Oncology
University of Alberta
Cross Cancer Institute
11560 University Avenue
Edmonton, Alberta T6G 1Z2
Email: xuejun.sun@albertahealthservices.ca

Xuejun SunThe Cell Imaging Facility at Cross Cancer Institute is a multi-user resource that enables researchers in the Institute and in the University of Alberta to implement imaging techniques in their research. The Facility focuses on applications of advanced, light microscopic imaging techniques (live cell imaging, FRAP, FLIM, FRET, Fluorescence Correlative Spectroscopy (FCS), etc.) in various aspects of Cancer/Cell biology research.

The Facility was established in 1998. Various light microscopic imaging instruments are available for local researchers (including confocal, multi-photon, deconvolution, Laser catapulting and high throughput FISH system, etc.). It is supported by CIHR (Canadian Institute of Health Research) and Alberta Cancer Board. Various research projects are currently conducted in the Facility. Briefly, main focuses of the department are: 1) Tumor biology; 2) DND damage and repair; 2) Cell cycle control and nucleus structure; 3) Role of transporter proteins in nucleoside biology and therapeutics.

Bitplane software has been a major imaging analysis tool for the Facility. Beside routine 3-D visualization with the software, Bitplane software enables us to conduct many complex image analyses which are impossible to do without it (e.g. 4-d tracking; co-localization analysis, quantifying DNA damage using image based analysis, etc.).

Please visit our web site at: http://www.oncology.med.ualberta.ca/AboutUs/FacultyMembers/Pages/ExperimentalOncology.aspx?P=7

Dr. Scott Fraser

Director
Biological Imaging Center
1200 E California Blvd.
Beckman Institute 139-74
Pasadena, CA 91125
E-mail: sefraser@caltech.edu

Fraser ApplicationScott FraserThe research at Scott Fraser's Biological Imaging Center explores the patterning of cell lineages, cell migrations and axonal connections during vertebrate embryogenesis. The goal is to develop new imaging techniques and experimental strategies that permit single-cell resolution studies of each of these key processes in intact developing embryos. Given that there is no single imaging technology or developmental model system that is ideal for all studies, we employ a parallel approach; we both consider various systems such as the frog, chicken or mouse and use techniques as diverse as video, laser scanning confocal, laser scanning two-photon, or magnetic resonance microscopy.

Please visit our web site at: http://bioimaging.caltech.edu/index_content.html

Dr. Michael Liebling

Biography:

Before joining UCSB in 2007, Michael studied Physics at EPFL (École Polytechnique Fédérale de Lausanne, Switzerland) and received the MS in 2000, with a diploma thesis on computerized tomography reconstruction. He was granted the PhD degree from the same institution in 2004 for a dissertation on Digital Holography and Image Processing that he completed under the advisory of Prof. Michael Unser at the Biomedical Imaging Group, EPFL. From 2004 to 2007, he was a Postdoctoral Scholar in the lab of Prof. Scott E. Fraser at the Biological Imaging Center, Beckman Institute, California Institute of Technology.

Electrical and Computer Engineering
University of California Santa Barbara
Mail Code 9560
Santa Barbara, CA 93106-9560
Email: liebling@ece.ucsb.edu

Our research interests are biological image acquisition, reconstruction, processing, and analysis. More specifically, we focus on developing novel microscopy instrumentation combined with the computational tools to enable dynamic, multi-modal, and in vivo cellular imaging during embryonic heart morphogenesis.

Please visit our web site at: http://sybil.ece.ucsb.edu

Dr. Andres Collazo

Director
Beckman Institute Biological
Imaging Facility
1200 E. California Blvd.
Pasadena, California
Email: acollazo@caltech.edu

I am the Director of the Beckman Institute Biological Imaging Facility (BIF; formerly called the Biological Imaging Center, BIC) at the California Institute of Technology (Caltech). My research is divided into multiple projects that study the development of the inner ear to better understand the cellular and molecular mechanisms underlying newborn deafness and other disorders resulting from genetic or environmental disruptions during inner ear development. Our new high-resolution imaging tools can provide an understanding of the dynamics of single protein molecules in the context of differentiating cells in living embryos.

My main research project utilizes a novel gene trap screen in zebrafish, done by our collaborators at Caltech. This FlipTrap screen generated hundreds of transgenic lines where full-length, endogenous proteins are tagged with a yellow fluorescent protein (citrine), allowing for high resolution imaging of labeled proteins and cells in intact, living embryos. A major goal of biology is to study the dynamics of single protein molecules in living animals, a potentially powerful tool for identifying abnormal protein function and understanding the molecular causes of medical disorders. This project advances this goal by using fluorescence correlation spectroscopy (FCS) to analyze quantitative properties of single fluorescently tagged proteins during vertebrate development. These data can be used to determine a protein’s mobility, concentration and binding kinetics; important properties for understanding protein function. The overarching goal of my research program is to push the limits of optical microscopy to study how proteins function in as close to in vivo conditions as possible.

  • Cornell University, Biology, B.S.
  • University of California at Berkeley, Zoology, Ph.D.

Please visit our web site at: http://www.its.caltech.edu/~bif

Dr. Aaron Ponti

ETH Zürich
D-BSSE Scientific Cent. Facilities
Mattenstrasse 26
4058 Basel
aaron.ponti@bsse.ethz.ch

In May 2012 Aaron Ponti joined the Department of Biosystems Science and Engineering of the ETH Zurich (in Basel) as a Software and Data Management Engineer in the newly established Single Cell Unit.

Aaron received a PhD at the Department of Mechanical and Process Engineering at the ETH Zurich in 2003 for his pioneering work on the development of a software platform for the analysis of Fluorescence Speckle Microscopy applied to the study of cell motility.

Aaron has worked at The Scripps Research Institute, San Diego, California as a post-doc and at Friedrich Miescher Institute in the Facility for Advanced Imaging and Microscopy.

Dr. I. Harper

Associate Professor
School of Biomedical Sciences
Faculty of Medicine
Nursing & Health Services








Ian Harper is the director of Monash Micro Imaging (MMI), a microscopy and imaging research support facility located at Monash University. MMI gives researchers access to the latest microscopes, as well as the expert instruction to tap into their full potential. MMI offers training, research support and project development in the areas of:

  • Optical and fluorescence microscopy
  • Confocal microscopy
  • Live cell imaging
  • Transmission electron microscopy (TEM)
  • Scanning electron microscopy (SEM)
  • Cryo methods for tissue preparation
  • Digital imaging and image analysis

http://microimaging.monash.org/index.html

Dr. Haruhiko Bito

Head of Department
Neurochemistry
Tokyo University

Our department's primary goal is to elucidate the basic signal transduction mechanisms which mediate key processes underlying various brain functions, such as learning, memory or emotion. A fundamental question is how an ensemble behavior of 10~100 billion neurons can possibly give rise to a coherent and integrated brain that controls the whole human organism for a period of more than 80 years.

What are the precise nature and the whole spectrum of the molecular changes in the neurons that undergo heavy or patterned electrical activity? What are the molecular rules that govern these local and global changes, both electrical and chemical? How are these events, in turn, converted into more profound modifications of the synaptic wiring mechanisms? And finally do these alterations genuinely underlie certain kinds of information processing and storage?

To address these issues, this Department currently focuses its resources into two basic aims:

1) Molecular investigation (including identification, characterization and real-time visualization) of signaling molecules involved in calcium-dependent synaptic modification, especially during signaling from synapse-to-nucleus, and back from nucleus-to-synapses.
2) Understanding molecular mechanisms controlling cytoskeletal dynamics and remodeling on both sides of the synapses, in the dendritic spines and in axon terminals.

Dr. Willy Supatto

Laboratory for Optics and Biosciences
Ecole Polytechnique
Palaiseau, France
Email: willy.supatto@polytechnique.edu

Biography:

  • MSc. in General Engineering, ESPCI Paris (2002)
  • MSc. in Biophysics, Paris VII University (2002)
  • Ph.D. in Biophysics, Institut Curie (2005)
  • http://willy.supatto.perso.sfr.fr/

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